Introduction

Product Name: Mebendazole 

Molecular Formula: C16H13N3O3

Molecular Weight: 295.2927

CAS Registry Number: 31431-39-7

EINECS: 250-635-4

Density: 1.388g/cm3

Melting point: 288.5°C

Refractive index: 1.702

Mebendazole or MBZ is a benzimidazole drug. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms

Function

Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells: thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. The drug is a highly effective broad spectrum antihelminitic indicated for the treatment of nematode infestations, including round worm, whip worm, thread worm, and hook worm. It is poorly absorbed and has no systemic effects.

Application

Mebendazole is a broad-spectrum anthelmintic drug. It has been proved in vivo or in vitro to directly inhibit the ingestion of glucose by nematodes, resulting in the depletion of glycogen, which makes it unable to survive, and has significant effects on killing larvae and inhibiting egg development. But does not affect the blood sugar level in the human body. It can be used to control intestinal parasitic diseases such as hookworm, aphid, aphid, whipworm and faecal nematode.