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CAS: 23180-57-6
English name: Paeoniflorin
EINECS: 245-476-2
Molecular formula: C23H28O11
Appearance: Paeoniflorin purity of 98% for the white crystalline powder
Boiling point: 683.3 ° C at 760 mmHg
Refractive index: 1.649
Flash point: 235.9 ° C
Density: 1.63 g / cm3

1. For the cerebrovascular system

To observe the effect of paeoniflorin on the changes of blood-brain barrier and cerebral ischemia-induced neuropathological changes and cerebral blood flow during reperfusion after cerebral ischemia. Paeoniflorin was found to have a protective effect on blood-brain barrier, cerebral blood flow and cerebral edema after cerebral ischemia. Focal cerebral ischemia animals using paeoniflorin. Can significantly reduce the extent of cerebral edema, reduce the range of cerebral infarction, increase cerebral blood flow, improve neurobehavioral symptoms, blood-brain barrier permeability. Paeoniflorin showed a significant protective effect on focal cerebral ischemic injury, the protective mechanism may be related to inhibition of intracellular calcium overload, anti-free radicals, to improve ischemic and hypoxic-induced cerebral vasomotor dysfunction, protection Cerebral ischemia during reperfusion during the blood-brain barrier and promote early cerebral perfusion after reperfusion and other effects of cerebral blood flow.

2. The role of the central nervous system

Paeoniflorin can significantly increase the survival of PC12 cells in the injury model, in vitro experiments on hypoxic-ischemic injury, Parkinson's disease and PC12 cells, glial cells and rat cerebral cortical neurons and other in vitro experiments confirmed that in vivo Can pass the blood-brain barrier, and then by (1) balance the ion channels: to prevent intracellular calcium overload, regulate sodium ion channels, regulate L-type calcium channels (2) Antioxidant: Reduce the level of oxygen free radicals, regulate nitric oxide and Nitric oxide synthase (3) Activates adenosine A1 receptor (4) Improves cholinergic function by (1) inhibiting apoptosis in vitro: prevents mitochondrial damage and regulates cell transduction pathways such as P38MAPKs, JNKs and ERK (2) promote nerve growth: promote peripheral nerve regeneration, affect the growth of cerebral cortex neurons (3) inhibit the activity of astrocytes to play a neuroprotective effect, so the paeoniflorin in neuroprotection have in-depth study of the value of paeoniflorin Through multiple channels, multiple targets inhibit nerve cell injury and apoptosis, have unique advantages in neuroprotection. However, paeoniflorin in the inhibition of nerve cell damage and apoptosis has its unique target.

The role of the tumor

Paeoniflorin has certain inhibitory effect on tumor cells, and paeoniflorin can inhibit the activity of ATPase and the activity of adenylate and cyclase on tumor cell membrane. The drug inhibits tumor cell formation, and inhibit the membrane Na, K-ATpase and activate AC is closely related.

The study found that paeoniflorin can inhibit the proliferation of human hepatoma cells to a certain extent to delay the progress of liver cancer.

4. Immunomodulatory effect

Paeoniflorin has some immunomodulatory function. Human peripheral lymphocytes is one of the main target cells for paeoniflorin to play a role in the body. Paeoniflorin may promote the immune regulation of Th1 / Th2 cytokines by inhibiting the excessive proliferation of peripheral lymphocytes and inhibiting the proliferation of peripheral blood lymphocytes. Paeoniflorin may provide a new experimental basis for the treatment of RA.

5 on the smooth muscle effects

Paeoniflorin may regulate the cell membrane calcium ion, sodium ion exchange to relax smooth muscle cells, paeoniflorin with the role of diastolic smooth muscle cells, and calcium reduction in paeoniflorin diastolic smooth muscle cells play an important role.

6. The impact on the blood

Paeoniflorin significantly increased the numbers of peripheral blood leukocytes and the number of CFU-GM / BFU-E / CFU-E / CFU-mix in bone marrow of radiation-induced hematopoietic mice and up-regulated the expression of Epo and G-CSF in bone marrow. Bone marrow hematopoietic growth factor EPO and G-CSF gene expression is one of the mechanisms to increase the number of peripheral white blood cells and promote the proliferation of various hematopoietic progenitor cells in radiation-induced blood deficiency mice.

7. Hypoglycemic effect

Paeoniflorin isolated from peony root and 8-benzoyl paeoniflorin can reduce the blood sugar in rats. Intravenous injection of paeoniflorin can significantly reduce the blood sugar of streptozotocin-induced diabetic mice, the plasma sugar content also decreases with the extension of medication time. Paeoniflorin hypoglycemic mechanism has nothing to do with insulin.

8. Other pharmacological effects

In recent years, the study also found that paeoniflorin with hepatoprotective effect, can inhibit cell division of lung cancer A549 cell line can stimulate the release of adenosine in cultured adipocytes to promote glucose metabolism, can protect cultured thymocytes from radiation damage.

Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian
International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the
leading researcher and one of the biggest manufacturer in high technology API area.

There are 8 experts in our research team. We insist in innovation and produce high quality
products. And GMP standard workshop and complete stainless extraction equipment.
We have 2 sales departments over 20 people and sell our products all over the world.

We also have strong professional research and development team, talented personnel and
completely equipped laboratory for the quality controlling. Various Detection Device is
equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto
titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

HNB mainly engaged in export of products including, without limitation, pharmaceutical raw
materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant
extract, feed and food additives.

Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and
Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends
from both home and abroad.

Passion to innovate, Power to deliver !