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We have specialized in this field for 7 years. our steroids and hormones have been exported to overseas, like europe, africa, asia, america and other countries. and we have got very good feedback from our customers, and established long friendly relations of cooperation.

High quality products with the best price

1.All powders are factory directly supplying and have much in stock.

2.Before each powder send out, it all will be tested again by our technician, if the quality good, then it can be sent out to customers.

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Best pre-sell and after-sell service.

1.Once the package send out, tracking number and packing picture should email you later

2.For raw powder buyer, we also can help you cook steroid powder into injection and supply you all the things to make ready use injection, such as 10ml vials,0.22um-0.45um whatman filter,crimper machine and filter pump.

High Quality Raw Material Telmisartan CAS 144701-48-4 for Hypertension Treatment

Telmisartan, chemically named 4 '-[4-methyl-6 -(1-methyl-1h-benzimidazol-2-yl) -2-propyl - 1h-benzimidazol-1-yl] biphenyl - 2-carboxylic acid, molecular formula is C33H30N4O2, white or white crystalline powder, odorless, tasteless. Soluble in trichloromethane, slightly soluble in dichloromethane or dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol, almost insoluble in water, soluble in 1mol/L sodium hydroxide solution, very slightly soluble in 0.1mol/L hydrochloric acid solution.

Function:

Non-peptide angiotensin ⅱ receptor antagonists selectively and irreversibly block ATI receptors without affecting other receptor systems. For mild to moderate hypertension. Telmisartan, a novel antihypertensive drug, is a specific angiotensin ⅱ receptor antagonist (AT ⅰ type) and is used in the treatment of essential hypertension. The replacement angiotensin ⅱ receptor binds with high affinity to the AT ⅰ receptor subtype (known angiotensin ⅱ action site). Telmisartan has no site agonist effect on AT ⅰ receptor site, and selectively binds to AT ⅰ receptor for a long time. There is no affinity for other receptors, including AT2 and other LESS characteristic AT receptors. The function of these other receptors is unknown, as is the possible overstimulation effect of telmisartan on angiotensin II levels. Telmisartan did not inhibit renin in human plasma or block ion channels. It did not inhibit angiotensin converting enzyme ⅱ, which could also degrade the adverse reactions caused by bradykinin enhancement. The elevated blood pressure induced by angiotensin ⅱ was almost completely inhibited by telmisartan 80mg in human. The inhibitory effect lasted 24 hours and could still be detected at 48 hours. The antihypertensive effect was gradually obvious within 3 hours after the first dose. Maximum hypotensive effects are achieved 4 weeks after the start of treatment and can be maintained over the long term. If treatment is abruptly interrupted, blood pressure gradually returns to pre-treatment levels after several days without rebound hypertension. In clinical trials that directly compared the two hypertension drugs, the incidence of dry cough was significantly lower in patients treated with angiotensin-converting enzyme inhibitors.