Nicotinamide mononucleotide plays an important role in energy generation of human cells, and it is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme of cellular energy conversion). Nicotinamide mononucleotide, a substance originally present in the body but reduced with age. Earlier experiments have confirmed that nicotinamide mononucleotide NMN can increase NAD in various organs in laboratory mice, thereby inhibiting aging of nerves and blood vessels, and improving diabetes symptoms.

β -nicotinamide mononucleotide is a precursor of NAD+, a cofactor of longevity protein in human body. NAD+ is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugar, fat and amino acids and participating in the synthesis of energy. NAD+ is also the sole substrate of coenzyme I consuming enzyme (PARP for DNA repair enzyme, Chemicalbook for longevity protein Sirtuins, cd38/157 for cyclic ADP ribose synthetase). NAD+ is involved in all aspects of human metabolism and is a key coenzyme. Without NAD+, the metabolism will not work. The elderly lack NAD+, so all kinds of problems come.

β -nicotinamide mononucleotide, also known as β -nicotinamide mononucleotide (NMN), is a synthetic substrate of coenzyme I, and NMN is also used in anti-aging studies. Keio University in Japan and the University of Washington in the United States are conducting human clinical trials on the anti-aging effects and safety of β-NMN. Studies have shown that β-NMN can also regulate the secretion of insulin and affect the expression level of mRNA. β -chemical BooKNMn has a wide application prospect in the field of medical treatment. β -nicotinamide mononucleotide is a product of extracellular nicotinamide phosphate ribotransferase (eNAMPT) reaction and a key NAD+ intermediate. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances liver insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response and circadian rhythm, partly through SIRT1 activation.

Nicotinamide mononucleotide, or NMN, is inherent in the human body and is also abundant in some fruits and vegetables, including broccoli and cabbage.

In mammals, β -nicotinamide mononucleotides are generated by Nicotinamide (Nam) in response to Nampt (a protease in vivo), followed by Nicotinamide mononucleotides in response to Nicotinamide adenosine transferase to NAD+. Nicotinamide mononucleotide is a direct way to supplement NAD+. Nicotinamide mononucleotide is the most Chemicalbook that ultimately reverses aging by significantly increasing the ability of cells to repair DNA damage. Nicotinamide mononucleotides are converted into nicotinamide adenine dinucleotides (NAD), which are essential for energy metabolism in the body. In mice, nicotinamide mononucleotides have been shown to activate a gene in the body called acetylase, which has been shown to have effects such as prolonging life and treating diabetes. NAD is a substance that the body naturally produces, and studies have shown that levels of NAD decrease with age.