IGF-1 LR3, also known as long arginine-3-IGF-1, is an analog of human IGF-1, which has been modified to include a 13 amino acid N-terminal extension and arginine-substituted glutamic acid position 3. As a result of these modifications, IGF-1 LR3 is approximately three times more potent than IGF-1 and has an increased half-life due to reduced affinity for binding to insulin-like growth factor binding protein (IGFBP). Compared to IGF-1, IGF-1 LR3 retains the ability to bind to the IGF-1 receptor with agonism with improved metabolic stability. Supplementation of mammalian cell cultures with long R3 IGF-1 at much lower concentrations resulted in higher productivity compared to standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more capable of stimulating type 1 IGF receptors, thereby inducing higher levels of intracellular signaling, which contributes to cell proliferation and inhibition of apoptosis.

Function of IGF1

1. Hypoglycemia: In this respect, IGF-1 is similar to insulin, can enhance the absorption of glucose and amino acids, promote the synthesis of glycogen and lactate secretion, inhibit the decomposition of glycogen, increase the body's sensitivity to insulin, and improve the body's insulin. Function efficiency. It has a good effect on insulin-independent diabetes (type II diabetes).
2. Lowering blood fat: IGF-1 acts on fat cells to promote lipolysis and glycogen synthesis, and lowers the levels of total triglycerides, very low-density lipoprotein triglycerides and low-density lipoprotein cholesterol in the blood.
3. Diastolic blood vessels: IGF-1 can regulate the physiological and pathological conditions of the heart, has diastolic blood vessels, reduces vascular resistance, and increases the blood flow of the heart.
4. Promote bone anabolism to maintain its normal structural function: IGF-1 can significantly promote the proliferation of chondrocytes from various sources and the synthesis of cartilage matrix. IGF-1 also stimulates chondrocytes to synthesize cartilage matrix-specific collagen-type II collagen, increase the activity of glycosaminoglycan, and enhance the activity of alkaline phosphatase of osteoblasts.
5. Growth promotion: IGF-1 is a very important cell mitosis promoter in the human body.
6. Promote cell differentiation: IGF-1 is important for maintaining protein levels related to cell differentiation, and in combination with some growth factors can promote cell differentiation and maturation.
7. Wound repair: IGF-1 is also involved in the process of wound healing. Experiments have shown that the concentration of IGF-1 is increased in injured nerve, muscle and scalp cells.

COA of IGF1